DICENTRINE PURIFIED FROM THE LEAVES OF OCOTEA PUBERULA CONTROLS THE INTRACELLULAR SPREAD OF L. (L.) AMAZONENSIS AND L. (V.) BRAZILIENSIS AMASTIGOTES AND HAS THERAPEUTIC ACTIVITY AS A TOPICAL TREATMENT IN EXPERIMENTAL CUTANEOUS LEISHMANIASIS

Leishmaniasis, a read more complex disease caused by protozoal parasites of the genus Leishmania, presents various clinical forms, particularly a cutaneous clinical form.Treatment is typically performed with pentavalent antimonial and amphotericin B, both of which have severe side effects that hinder patient compliance.This emphasizes the need for

Vaccine hesitancy regarding the coronavirus disease 2019 (COVID-19) vaccine is widespread during the COVID-19 pandemic.Many recent studies have reported that the confidence of the vaccination and perceived risk were associated with vaccination intent, yet few studies have focused on other psychological factors.This study aimed to clarify the trends

We used publicly available land-cover datasets (1921, 1947, 1976, 1992, 2001, 2006, 2014) to assess land-cover change on Babeldaob Island, Republic of Palau.Land-cover data were organized, classified, and summarized by area and percentage of island cover for forest, mangrove, non-forest vegetation, and non-vegetation.Japanese colonial administratio

Abstract: Therapy-related acute myeloid leukemia and myelodysplastic syndromes (t-AML/t-MDS) are secondary hematologic malignancies associated with poor prognosis, warranting insights into their predisposing conditions and cells of origin.We identified patients with myeloma who developed t-AML/t-MDS and analyzed their stem and progenitor cells coll

The relevance of the topic under consideration is due to the fact that in modern conditions, in order to combat administrative and criminal offenses, along with bodies operating within the framework of public legal regulation, various types of entrepreneurial activities operating within the framework of private legal means of legal regulation conti